The reliability analysis based on performance degradation data has become an effective and economic assessment approach in nowadays.The existed researches mainly limited to one performance measure.However, many products have multiple performance measures.Therefore, we proposed a reliability analysis approach based on multivariate distance analysis, and presented the concepts of multiple performance measure distance and failure threshold of distance.A method for solving the weights was also given, which could compensated for shortcoming of complexity of the existed method based on the assumption of multivariate normal joint probability density function.Simulation examples demonstrated the validity of this approach.