The decision-making problem of multi-UAV cooperative air combat based on game iteration is studied.Firstly, based on the combat situation of the two sides and effectiveness parameters, the matrix game method is used to establish the confrontation payoff game model of the two sides to obtain the payoff matrix.Then, according to the definition of the mixed strategys Nash equilibrium and its derivation process, the method for solving the mixed strategys Nash equilibrium in air combat using game iteration is obtained and the steps are given.Finally, simulation examples have verified the feasibility and effectiveness of the method, which provides a valuable reference for solving multi-UAV air combat strategies.