Researching blasting similar simulation materials for ultra-deep shaft surrounding rock and conducting physical model tests are the basis for studying the dynamic response law of ultra-deep shaft surrounding rock under blasting. This paper used the monzonitic granite in Xiling subsidiary shaft of Sanshandao gold mine as the simulation object to prepare similar granite materials. The iron ore powder and barite powder were selected as fine aggregates, the quartz sand was selected as coarse aggregate, the rosin alcohol solution was selected as binding material, and the gypsum was selected as adjusting material. The orthogonal design method was used to prepare the simulation materials. The mechanical parameters of similar materials with different proportions were determined, and the sensitivity analysis of each influencing factor and the blasting test of the simulated materials were carried out. The results show that the selected proportion can meet the requirements of indoor blasting model tests based on the specimen's density, unaxial compressive strength and elastic modulus. The proportion of fine aggregate in the total aggregate significantly affects the density of the simulated materials. The binder concentration significantly affects the compressive strength, tensile strength, elastic modulus and cohesion of the simulated materials. The proportion of gypsum significantly affects the internal friction angle of the simulated materials. The peak strain value in the model test block under high confining pressure is more significant as a whole, and the attenuation rate of the peak strain gradually decreases with the distance increase.