Light emitting diode (LED) focusing lens with angle deflection for machine vision is designed by optical modeling software Light Tools. The lens is made of polymethyl methacrylate (PMMA). Firstly, the LED model is built according to the working distance and the illumination size. Secondly, a total reflection lens model is established with a lens model inside, and the illumination gridding optimization function is made to obtain the uniform illumination in the target area. Lastly, the lens is cut with tilted angle to meet the requirements of the angle based on the refractive law. The lens has simple structure, good uniformity, and it is easy to achieve the processing requirements. The lens meets the requirements of the angle deflection in the machine vision field.