The chamber environment of a laser inertial confinement fusion (ICF) driver is usually complex. Specifically, signals will be affected by the coupling currents induced by ionizing radiation and electromagnetic radiation during the laser shots. In this paper, radiation responses of two kinds of shielded cables are calculated by using the self-written code and CST software, respectively, and the irradiation experiment is carried out based on SG-Ⅲ laser driver, with the results compared and analyzed. It is found that the electromagnetic radiation response of the RG142 cable is slight, but its ionizing radiation is strong, which is the opposite of the CERN SPA6 cable. Finally, according to the coupling law, a composite shielding structure of cable is proposed.