This paper discusses the possibility of selectively eliminating the intra-molecular vibrational redistribution (IVR) in polyatomic molecules by using a strong resonant microwave (MW) field. The results show that when the MW intensity is strong enough, IVR process is significantly eliminated, and the initially prepared local mode vibrational state can be long-lived. This approach may avoid the difficulty caused by the possible multi-photon dissociation, so that it may be used in the practical case.