Taking the controlled blasting engineering of subgrade of a construction project as the research background,the blasting parameters and safety protection measures are designed to eliminate the potential safety hazards caused by blasting flying stones and vibration caused by subgrade blasting to the adjacent glass curtain wall.The design includes:More holes and less charge are used to drill dense holes with a spacing of 2.5 m×2.2 m,and a rectangular hole layout method is selected to facilitate covering and protection,By controlling the charge and filling quality of single hole,the uniformity of blasting energy release is ensured;In the way of cutting blasting,a method of simultaneous initiation of two holes in the millisecond delay initiation network is selected,and the delay time of each hole is set reasonably to avoid the phenomenon of section stacking and reduce the adverse impact of blasting vibration;In terms of safety protection,the advantages and disadvantages of the two safety protection measures of the quilt made of old tires cover and the quilt made of dense-mesh-pressurization old tires cover are compared.After comprehensive consideration,the safety protection measure of dense-mesh-pressurization old tires cover is selected.The engineering practice shows that the glass curtain wall is safe and nondestructive,and the blasting effect is good.Compared with the conventional full coverage protection method of blast holes,it not only effectively controls the harmful effects such as blasting vibration and blasting flying stones,but also reduces the protection workload,saves the protection cost and reduces the probability of damaging the network during protection.The successful application of the blasting parameters and safety technical measures can provide reference for similar projects to a certain extent.