In order to change the present situation of horizontal drawing forming of glass tube based on intuitive knowledge and empirical design, a numerical simulation model of heat and mass transfer in horizontal drawing process of glass tube was established by using ANSYS Polyflow software, then the changes of temperature field, velocity field, pressure field, viscosity field and so on were obtained. Through the numerical simulation analysis, it is concluded that the molten glass inflow temperature, pulling speed, blowing air inflow pressure and rotating cylinder rotational speed are all the sensitive technological parameters affecting the glass tube forming. The molten glass inflow temperature and blowing air inflow pressure are directly proportional to the outside diameter of glass tube and inversely proportional to the wall thickness of glass tube. The pulling speed is inversely proportional to both the outer diameter and the wall thickness of glass tube, and the rotating cylinder rotational speed is directly proportional to the eccentricity of the forming position. The numerical simulation model proposed in this paper will provide theoretical support for improving the quality of glass tube, shortening the replacement adjustment time, improving production efficiency, and saving material and energy consumption.