Spectroscopy and Spectral Analysis, Volume. 30, Issue 2, 518(2010)

Simultaneous Correction for Blood Matrix Effect on Determination of Magnesium, Copper and Lead Concentration in Blood Samples by ICP-MS Using CAIS

YANG Le1, ZENG Jing1,2, WANG Xiao-yan1,2, WU Zan3, CHI Hai-tao3, OUYANG Li1,2, ZHANG Jing-hua3, and WANG Jing-yu1,2、*
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  • 1[in Chinese]
  • 2[in Chinese]
  • 3[in Chinese]
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    The influence of matrix effect on the determination of magnesium, copper and lead in human blood matrix stimulant and its correction was studied by using both conventional internal reference method & common analyte internal standardization (CAIS). The obtained results indicate that CAIS method is applicable for simultaneous correction of multi-elements in blood matrix. The relative errors between the determined and the true values are 3.05% (by CAIS method), 12.39% (by conventional internal reference correction) and 23.91% (without correction), respectively. Otherwise, the influences of the mass discrepancy and that of the determination intensities between elements are not obvious for the correction of blood matrix. The reliability of CAIS was validated by the determination of both bovine blood and bovine serum standard materials.

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    YANG Le, ZENG Jing, WANG Xiao-yan, WU Zan, CHI Hai-tao, OUYANG Li, ZHANG Jing-hua, WANG Jing-yu. Simultaneous Correction for Blood Matrix Effect on Determination of Magnesium, Copper and Lead Concentration in Blood Samples by ICP-MS Using CAIS[J]. Spectroscopy and Spectral Analysis, 2010, 30(2): 518

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    Paper Information

    Received: Feb. 28, 2009

    Accepted: --

    Published Online: Jul. 23, 2010

    The Author Email: Jing-yu WANG (wjy@bjmu.edu.cn)

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