Aiming at the infrared imaging guidance system with good maneuverability and strong penetration ability, a new type of infrared interference method was proposed by using the characteristics of ultra-thin metal sheets that can quickly heat up and naturally cool down. A mathematical model of the heating and natural cooling process of the metal sheet was established, and the structure and material of the metal sheet were determined; the infrared interference device with a simple structure and a good sealing environment was designed. The test results indicate that the nickel sheets is the best material. The heating time is 50 ms (500-1 000 ℃), and the natural cooling time is 75 ms (1 000-500 ℃), which meet the frame rate requirement (10 Hz). And the regular periodic change of temperature is realized. The analysis and test results confirm that the device can simulate the rapid changes of infrared radiation characteristics, and could provide a new idea for interference in the terminal guidance phase.