Chinese Optics Letters, Volume. 8, Issue 11, 1075(2010)

Fluorescence molecular tomography system for in vivo tumor imaging in small animals

Jianwei Fu, Xiaoquan Yang, Guotao Quan, and Hui Gong
Author Affiliations
  • Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China
  • show less

    A fluorescence molecular tomography system for in vivo tumor imaging is developed using a 748-nm continuous wave diode laser as an excitation source. A high sensitivity cooled charge-coupled device (CCD) camera with excitation and emission filters is utilized to obtain the excitation and fluorescence images. The laser beam performs fast raster scanning using a dual-axis galvanometric scanner. The accuracy of the laser spot position at the source window is within +-200 \mum. Based on the phantom experimental results, the spatial resolution is less than 1.7 mm, and the relative quantitation error is about 10%. In vivo imaging of a tumor-bearing nude mouse tagged with near-infrared dye demonstrates the feasibility of the system.

    Tools

    Get Citation

    Copy Citation Text

    Jianwei Fu, Xiaoquan Yang, Guotao Quan, Hui Gong. Fluorescence molecular tomography system for in vivo tumor imaging in small animals[J]. Chinese Optics Letters, 2010, 8(11): 1075

    Download Citation

    EndNote(RIS)BibTexPlain Text
    Save article for my favorites
    Paper Information

    Received: Mar. 16, 2010

    Accepted: --

    Published Online: Dec. 3, 2010

    The Author Email:

    DOI:10.3788/COL20100811.1075

    Topics