The Huai radix rehmanniae at different grades was pretreated by wet digestion, and then the metal elements in the radix rehmanniae and the prepared sample by steaming method were determined using ICP-MS. The results indicate that there is no obvious difference in the metal elements between the different grades and between the dried radix rehmanniae and its corresponding prepared product. There are elements Zn, Cu, Cr, Fe, Mn, Sn, Ni, Mo, Go, etc. in radix rehmanniae, among which the contents of Ca, Fe, Al, Zn and Cu are higher; the metal elements beneficial to human body in dried radix rehmanniae are relative lower than that in the prepared one. The elements such as Co, Ni, Cr, Mn, etc. in radix rehmanniae have poison effects on human body when their contents are more than a certain threshold value, although they are human essential elements. Element Pb is harmful to human body, which should be controlled and reduced/eliminated in the processing procedure. The determination and comparison of the metal elements in radix rehmanniae at different grades can provide useful information about the comprehensive evaluation of dried radix rehmanniae and their prepared products.