Acta Optica Sinica, Volume. 29, Issue 10, 2860(2009)

Gastric Cancer Detection Using Diffuse Reflectance Spectral Ratio R540/R575 of Oxygenated Hemoglobin Bands

Li Lanquan1、*, Wei Huajiang1, He Bohua2, Guo Zhouyi1, Yang Hongqin3, Xie Shusen3, Chen Xuemei4, Li Libo2, Wu Guoyong5, and Lu Jianjun5
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  • 2[in Chinese]
  • 3[in Chinese]
  • 4[in Chinese]
  • 5[in Chinese]
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    Differential diagnosis of epithelial tissues of normal human gastric,undifferentiated gastric adenocarcinoma,gastric squamous cell carcinomas,and poorly differentiated gastric adenocarcinoma were studied using the mean diffuse reflectance spectral ratio (R540/R575) of the oxygenated hemoglobin absorption bands. Exvivo diffuse reflectance spectra in the 400 nm to 600nm region was measured from surgically removed gastric lesions using a spectrophotometer with an integrating sphere attachment. The results showed that the reflectance spectral intensity of the malignant tissues was lower than that of human normal gastric tissues and showed dips at 540 nm and 575 nm owing to absorption from oxygenated hemoglobin. Measurements carried out,the diffuse reflectance spectral ratio for epithelial tissues of normal human gastric,undifferentiated gastric adenocarcinoma,gastric squamous cell carcinomas,and poorly differentiated gastric adenocarcinoma were (94.2±2.4)%,(109±3.0)%,(103±2.8)% and (98.6±2.6)% respectively.

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    Li Lanquan, Wei Huajiang, He Bohua, Guo Zhouyi, Yang Hongqin, Xie Shusen, Chen Xuemei, Li Libo, Wu Guoyong, Lu Jianjun. Gastric Cancer Detection Using Diffuse Reflectance Spectral Ratio R540/R575 of Oxygenated Hemoglobin Bands[J]. Acta Optica Sinica, 2009, 29(10): 2860

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    Paper Information

    Category: Medical optics and biotechnology

    Received: Dec. 16, 2008

    Accepted: --

    Published Online: Oct. 19, 2009

    The Author Email: Lanquan Li (lilanq@yahoo.cn)

    DOI:10.3788/aos20092910.2860

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