The COVID-19 pandemic since 2019 has brought huge impacts and economic losses to the world. AlGaN-based deep-ultraviolet light emitting diode (DUV-LED) as a new and efficient sterilization device has attracted broad research attentions. The transparent electrode covering deep-UV band plays an important role in improving the performance of deep-UV LEDs. Here, we propose a novel core-shell structure Cu@metal nanosilks (Cu@metal NSs) network electrode with high transparency (>90%) to enhance the output power of deep-UV LED. In addition, based on the optimized design of integrated array module of deep-UV LEDs, a 180 mW DUV-LED sterilization device is fabricated. The device shows high inactivation performance for Escherichia coli and Staphylococcus aureus (>99.99%) and for COVID-19 virus (>99.9%). This work provides a novel method for improving the performance of deep-UV LEDs and pushing forward the efficient sterilization applications.