The hardware and software of the control system on laser processed multiple degree of freedom worktable are designed. A programmable multi-axis controller (PMAC) is chosen as the key controller to control 5 motion axes during laser processing. The communication method between PC and PMAC through double-port random access memory (RAM) is introduced,which greatly improves the communication speed of the system. A visible man-machine interactive interface is designed to provide a friend interactive window for user communication control system. The writing processes of PMAC motion and PLC programs are described,which provides guidance for users to develop programs autonomously. These research and analysis have important reference value for hardware design and software development.