The dynamic response characteristics such as deformation capacity,acceleration,and load transfer of high-rise frame structure buildings under the condition of single column failure in different parts were studied.Firstly,according to the Code for Design of Concrete Structure (GB50010),a 4×6 span 8-story reinforced concrete frame structure model was established by using PKPM design software.Secondly,based on the component removal method,the finite element software SAP2000 was used to calculate the dynamic response characteristics of the frame structure with the failure of different single columns at the first floor,including the center column,long side middle column,short side middle column and corner column.The results show that the plastic angle is less than 6 for all the four column failure conditions,and the structure will not collapse.When the central column fails,the structural stability is the worst,and the probability of continuous collapse is the highest,followed by that of the short side and long side middle columns,and the corner column has the least probability.Under the condition of center column failure,the dynamic impact of the load on the residual structure is the most significant,with a maximum negative acceleration of about 3 g,which is twice as high as that of the short side middle column and the long side middle column.After the failure of the columns,the loads will be redistributed.The axial force will be borne by the adjacent columns,while the stress form of the upper beam will also change from bending to tension,resulting in a catenary effect.In the scenario of the central column failure,the axial force of the adjacent columns will increase by nearly 20%.