It is an important research area to quantitatively studying the relationship between global climatic change and vegetation change based on the remote sensing technology. Panxi area is the ecological barrier of the upper reaches of the Yangtze River, and it is essential for the stability of the ecological environment of Sichuan as well as that of the whole China. The present article analyzes the vegetation change in 2001—2008 and the relationship between vegetation change and climatic variations of Panxi area, based on MODIS multispectral data and meteorological data. The results indicate that NDVI is positively correlated with temperature and precipitation. The precipitation is the major factor that affects the change of vegetation in the Panxi region and the trend of NDVI is similar with autumn precipitation; while at the same time the influence of climate has a one-month- time-lag.