An octopole reaction system (ORS) inductively coupled plasma mass spectrometry (ICP-MS) was developed for the determination of Mg, Ti, V, Cr, Fe, Co, Ni, Cu, Zn, As, Cd and Pb in edible phosphate. The sample was digested by HNO3 followed by dilution with ultrapure water, then the above 12 impurity elements in the solution were analyzed directly by ICP-MS. The use of ORS can eliminate the interference of polyatomic ions dramatically. Sc, Y, In and Bi were used to correct the matrix interference and drift. The detection limits of the 12 elements are in the range of 0.004～0.362 μg·L-1. This method is rapid, simple and applicable for the analysis of trace elements in edible phosphate.