Optical coherence tomography (OCT) is employed in the diagnosis of skin cancer. Particularly, quantitative image features extracted from OCT images might be used as indicators to classify the skin tumors. In the present paper, we investigated intensity-based, texture-based and fractalbased features for automatically classifying the melanomas, basal cell carcinomas and pigment nevi. Generalized estimating equations were used to test for differences between the skin tumors. A modified p value of <0.001 was considered statistically significant. Significant increase of mean and median of intensity and significant decrease of mean and median of absolute gradient were observed in basal cell carcinomas and pigment nevi as compared with melanomas. Significant decrease of contrast, entropy and fractal dimension was also observed in basal cell carcinomas and pigment nevi as compared with melanomas. Our results suggest that the selected quantitative image features of OCT images could provide useful information to differentiate basal cell carcinomas and pigment nevi from the melanomas. Further research is warranted to determine how this approach may be used to improve the classification of skin tumors.