Journal of Innovative Optical Health Sciences, Volume. 7, Issue 3, 1350059(2014)
Synthesis of biocompatible near infrared fluorescence 2 quantum dot and its application in bioimaging
Near infrared (NIR) emitting quantum dots (QDs) is a promising candidate for biomedical imaging in living tissues. However, the biomedical application of NIR QDs was not satisfactory due to their toxicity. 2 QDs was reported to have negligible toxicity in organisms. Therefore, the appropriate narrow bandgap and low toxicity of 2 QDs facilitated them to be a promising contrast agent for fluorescence imaging. Here, a low toxicity, stable and highly luminescent NIR 2 QDs were prepared by one-step aqueous method using 2-mercaptopropionic acid (MPA) as the coating layers. Emission wavelength of 2 QDs could be tuned between 780 and 950 nm. MTT assay results indicated that there was no significant biotoxicty for 2 QDs. These NIR QDs exhibited excellent biocompatibility in tumor cells. The cellular uptake and localization of 2 QDs was studied using laser confocal scanning microscopy. 2 QDs were effectively internalized by the cells. Therefore, 2 QDs, acting as a novel fluorescence probe, has promising potential in biolabeling, deep tissue imaging, diagnostics and photodynamic therapy.
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Xin Zhang, Yueqing Gu, Haiyan Chen. Synthesis of biocompatible near infrared fluorescence 2 quantum dot and its application in bioimaging[J]. Journal of Innovative Optical Health Sciences, 2014, 7(3): 1350059
Received: May. 31, 2013
Accepted: Sep. 15, 2013
Published Online: Jan. 10, 2019
The Author Email: Gu Yueqing (guyueqingsubmission@hotmail.com)