With the rapid development of light-emitting diodes, LED lighting technology is increasingly being used in various industries, and similar medical, printing, textile, beauty, and other industries require high color performance capability of LED lamps. Still, at the same time, the photobiological hazards brought about by LED lamps are also increasingly being paid attention to, among which is the LED blue light hazard, which is the most well-known. In recent years, many researchers have committed to reducing the blue light hazard of white LED. Still, most of them are in the case of low correlation color temperature to obtain the corresponding white light spectrum or through a section of the correlation color temperature range of the lowest blue light radiation efficiency of the correlation color temperature of the discrete exhaustive to find out the lowest blue light hazard of the spectra, can be obtained in different target correlation color temperature at the same time have a high color performance ability and low blue light radiation efficiency. The ability to obtain high color performance and low blue light hazard radiation efficiency at different target-relevant color temperatures of hybrid white LED spectra is almost non-existent. Based on the existing multiple LEDs, this paper proposes a nonlinear constrained optimization method with a simple objective function. Previous studies found that the blue light hazard-weighted radiant flux shows a linear relationship with its associated color temperature. As its associated color temperature increases, the blue light-weighted radiant flux also increases. Fix its relevant color temperature to obtain a white LED spectrum with low blue light hazard. You will get the blue light-weighted radiation flux corresponding to each targets relevant color temperature. According to the formula for evaluating the radiation efficiency of the blue light hazard of the LED light source, the numerator is fixed and only needs to maximize the denominator; the blue light hazard radiation efficiency will be minimized, so maximizing the radiation efficiency can be. For spectral power distribution, the spectral power distribution of the selected multiple LEDs is limited by using a filter, and at the same time, because of the actual production requirements to add a smoothing constraint on the spectral transmittance of the filter, and the smoothing constraint is accomplished by the method of weighted average. Finally, the radiation weight of each color LED is obtained by maximizing the “RP” method. The simulation experimental results prove that the method in this paper can ultimately obtain eight target-relevant color temperatures from 2 700 to 6 500 K by ANSI/NEMA C78.377-2017 standards, which are 2 700, 3 000, 3 500, 4 000, 4 500, 5 000, 5 700 and 6 500 K, and the spectra of the light sources under each CCT with their Color rendering index, color fidelity, color gamut index are above 90, color deviation value within 0.0054, blue light hazard radiation efficiency are within 0.1 of the hybrid LED white light spectrum.