Considering the function requirement of hardware-in-the-loop simulation control platform for a certain guided weapon, we put forward a system design idea based on VMIC real-time network and Ethernet. The design scheme and realization approaches are introduced. A real-time Automatic Test System (ATS) is developed by using RTX subsystem together with LabWindows/CVI. By the use of integrated hardware design and modularized software design, the control platform can implement such functions as real-time video signal acquisition to the seeker, data recording and processing, real-time flight data curve displaying, real-time monitoring and status indication, video playback, and fault diagnosis and treatment. The control platform has the characteristics of fine real-time performance, universality and expansibility, which can support the hardware-in-loop simulation effectively and provide a technical support for weapon system development and test.