To improve the low-temperature oxidation resistance of MoSi2, a core-shell structured MoSi2@SiO2 was prepared by a direct preoxidation method, and the preoxidation conditions, as well as the structure and the low-temperature oxidation resistance of MoSi2@SiO2 composite, were investigated. Results show that the core-shell structured MoSi2@SiO2 can be obtained under preoxidation at 800 ℃ for 1 h. The obtained SiO2 shell is amorphous which is formed due to the non-selective oxidation of MoSi2 and the evaporation of the oxidation product MoO3. The oxidation mass gain rate of MoSi2@SiO2 is <1.6% after isothermal cyclic oxidation at 400-700 ℃ for 12 h.