This study demonstrates an all-solid-state acousto-optic Q-switch Nd∶YAG laser with a high repetition rate and high pulse energy. A master oscillator power amplifier system with a thermal-compensation cavity of connecting two Nd∶YAG rods in series and an amplifier containing a two-slab gain medium is selected for the experiment. Fused silica is used as the acousto-optic Q-switch crystal with an adjustable repetition rate of 10-100 kHz. At the repetition rate of 10 kHz, the linearly polarized laser with an output power of 14 W is injected into the two-slab gain medium for amplification after beam expanding and sharping. When the pump power is 22.7 kW, a laser output power of 4256 W is obtained with a pulse energy, pulse width, and peak power of 425.6 mJ, 133 ns, and 3.2 MW, respectively. The laser beam quality β is 3.8 times of the diffraction limit. The output power and pulse width at different repetition rates are kept constant during the experiment.