Functional surfaces with special wettability have played an important role in society and our daily life. Meanwhile， femtosecond laser has become an important tool to prepare a special wetting surface because of its unique manufacturing advantages. This article discusses the method of fabricating various microstructures by femtosecond laser， that is based on the connection between biological surface microstructures in nature and their practical applications. Then， three aspects of the preparation of the surface with special wettability via femtosecond laser are reviewed which are the “Janus” surfaces， the smart response surperhydrophobic surfaces， and the slippery surfaces. By summarizing the research results of the surface with special wettability prepared by femtosecond laser， this review provides a reference for the research， application， and future research direction of special wetting surfaces using a femtosecond laser.