In order to improve the security and reliability of the image in the information exchange, a new method was put forwards that laser speckle and Henon mapping were mixed and applied to the image encryption in this paper. Laser speckle image gray distribution was random, it could be scanned for difference random sequences by using the SCAN language. A sequence generated by this sequence with Henon mapping that sum modulo form a new sequence. Using the new sequence to made bit-wise exclusive or implement encryption with original images to be encrypted. The results showed that the method has a good encryption effect, strong key sensitivity and weak correlation of adjacent pixels, could against the statistical attack.