Zoom lens has increasing applications for its inherent properties. At present, the continuous zoomed lens generally adopt the mechanical－compensated optical configuration in which the given variable lenses groups move along the optical axis driven by a cam to achieve the continuous change of EFL , and it usually has two or more variable groups. Its cam optimization is the key to actualize the performance of its optical design and the zooming process, while the smoothness and speediness of zooming movement must be considered for a military use. The cam optimization method of a mechanical－compensated zoom lens with two variable groups is briefly described and the main body of the Macro－PLUS sequence which is suitable for different numbers of cam data points and optical design of the zoom lens with two variable groups are given.