In brick-tea fluorosis affected areas XiLinHot city in Inner Mongolia, herdsmen who like drinking a large amount of brick tea in everyday life and Han habitants rarely drinking brick tea as control group were enrolled, and their hair and urine were sampled. The concentrations of Ca, Mg, K, Al, P, Cu, Zn and Fe in hair and urine were detected using ICP-OES. The RSDs of the method were between 2.32% and 8.03%, and the analytical results of the hair reference samples were consistent with the certified values. The results showed that the contents of Al, Mg and K in hair, and contents of Al and Ca in urine of herdsmen who were accustomed to drinking brick tea were obviously higher than those in control group (P＜0.05), while the contents of K in urine of herdsmen who were accustomed to drinking brick tea was lower than those in control group (P＜0.05), and other elements did not have statistic significance (P＞0.05). Chronically drinking brick tea probably brings metabolic disorder of Ca and Al in human body, and the interaction mechanism of life elements in brick-tea fluorosis should be further studied.