As typical solid wastes, slag powder, fly ash and silica fume were used as raw materials to fabricate solid waste shield inert synchronous grouting materials. The mechanical property and resistance to water dispersion of grouting materials were investigated by using six-factor and five-level orthogonal test. The results show that the compressive strength of slurry decreases with the increase of alkali activator modulus and the decrease of dosage. The water-binder ratio and bentonite-water ratio exhibit great influence on the hydrodynamic erosion resistance of slurry. The dosage of alkali activator and the water-binder ratio are the main factors affecting the water land strength ratio of slurry. According to the range analysis of orthogonal test and comprehensive performance balance, the optimal mix ratio of grouting material is determined as follows： water-binder ratio 1.00, binder-sand ratio 0.45, bentonite-water ratio 0.35, dosage of water reducer 1.5% （mass fraction）, alkali activator modulus 1.6, dosage of alkali activator 20% （mass fraction）, and grouting material exhibits compressive strength (28 d) of 13.02 MPa, water land strength ratio of 80.83% and hydrodynamic erosion mass loss rate (3 h) of 5.62%. Furthermore, performance tests such as consistency, setting time, bleeding rate and stone rate were conducted, and the indexes all met the requirements of active slurry. The above research provides a certain research and experimental basis for the application of industrial solid wastes in the field of shield grouting technology.