We developed a novel method for real-time monitoring of alteration of the local epithelium vessel/capillary and blood oxygenation spatial pattern in epithelium exploiting a compact fibre sensor system based on spatially and spectrally resolved diffuse reflectance. The method is based on collection of spatially resolved diffuse reflectance R（λ） by fiber sensors. The spatial resolution is provided as a dependence of R（λ） on a set of distances ρ between the source and detector (attenuation curve). It is expected that the new method can reasonably extract the minor spatial deviations of oxygenation and local blood volume fraction — parameters, directly related to the local vessel density and capillary spatial patterns in the epithelium. Light scattering in visible range is naturally taken into account in the proposed method.