The ternary TeO2-Nb2O5-YF3 glass was synthesized and the formation range of TeO2-Nb2O5-YF3 glass system was investigated. The density, refractive index, differential thermal property (DTA), Raman spectra, UV absorption spectra and infrared transmission spectra of the samples were tested. The effects of composition content change on the structure and infrared transmission properties of glasses were investigated by spectra analysis. The results show that the glass forming ability and thermal stability of the ternary TeO2-Nb2O5-YF3 glass are good. The presented oxyhalide tellurite glass exhibits a high transmissivity (80%) in the mid-infrared regions (3～5 μm). There is no evident [OH] absorption bands in the range of 2.8～3.3 μm.