Visually induced motion sickness has become a serious problem for users of virtual reality technology. Users immersed in a virtual reality environment generally suffer from dizziness, vomiting, and other symptoms. The distortion in stereoscopic image acquisition leads to virtual space distortion in human perception, which may be an important factor inducing and enhancing visually induced motion sickness. To study the effect of the distortion of stereoscopic video acquisition on visually induced motion sickness, a virtual spatial distortion model is constructed based on the theory of stereoscopic video acquisition. In addition, different levels of stereoscopic spatially distorted videos are obtained from lenses with three focal length parameters. Visual perception experiments were conducted to objectively and subjectively evaluate visually induced motion sickness under different spatial aberrations. The results show that when the angle of view of the acquired stereoscopic video does not match the stereoscopic visual angle of human eyes, the distortion of the video significantly affects the visually induced motion sickness, and the distortion of the stereoscopic video acquisition results in a more intense visually induced motion sickness. This paper presents a novel and systematic method to experimentally verify that distortions in virtual space caused by the mismatch between acquisition and perception parameters enhance visually induced motion sickness. The findings of this study can help put forward practical mitigation methods.