Journal of Innovative Optical Health Sciences, Volume. 7, Issue 1, 1450013(2014)

COHERENT HEMODYNAMICS SPECTROSCOPY BASED ON A PACED BREATHING PARADIGM — REVISITED

JANA M. KAINERSTORFER, ANGELO SASSAROLI, MICHELE L. PIERRO, BERTAN HALLACOGLU, and SERGIO FANTINI
Author Affiliations
  • Department of Biomedical Engineering, Tufts University 4 Colby Street, Medford, MA 02155, USA
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    A novel hemodynamic model has been recently introduced, which provides analytical relationships between the changes in cerebral blood volume (CBV), cerebral blood flow (CBF), and cerebral metabolic rate of oxygen (CMRO2), and associated changes in the tissue concentrations of oxy- and deoxy-hemoglobin (△O and △D) measured with near-infrared spectroscopy (NIRS) [S. Fantini, Neuroimage 85, 202–221 (2014)]. This novel model can be applied to measurements of the amplitude and phase of induced hemodynamic oscillations as a function of the frequency of oscillation, realizing the novel technique of coherent hemodynamics spectroscopy (CHS) [S. Fantini, Neuroimage 85, 202–221 (2014); M. L. Pierro et al., Neuroimage 85, 222–233 (2014)]. In a previous work, we have demonstrated an in vivo application of CHS on human subjects during paced breathing [M. L. Pierro et al., Neuroimage 85, 222–233 (2014)]. In this work, we present a new analysis of the collected data during paced breathing based on a slightly revised formulation of the hemodynamic model and an efficient fitting procedure. While we have initially treated all 12 model parameters as independent, we have found that, in this new implementation of CHS, the number of independent parameters is eight. In this article, we identify the eight independent model parameters and we show that our previous results are consistent with the new formulation, once the individual parameters of the earlier analysis are combined into the new set of independent parameters.

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    JANA M. KAINERSTORFER, ANGELO SASSAROLI, MICHELE L. PIERRO, BERTAN HALLACOGLU, SERGIO FANTINI. COHERENT HEMODYNAMICS SPECTROSCOPY BASED ON A PACED BREATHING PARADIGM — REVISITED[J]. Journal of Innovative Optical Health Sciences, 2014, 7(1): 1450013

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    Paper Information

    Received: Oct. 2, 2013

    Accepted: Nov. 27, 2013

    Published Online: Jan. 10, 2019

    The Author Email:

    DOI:10.1142/s1793545814500138

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