Advanced Fiber Materials, Volume. 6, Issue 2, 00364(2024)

An Asymmetric Natural Nanofiber with Rapid Temperature Responsive Detachability Inspired by Andrias davidianus for Full-Thickness Skin Wound Healing

Zhe Huang1、†, Heng An1、†, Haitao Guo2,4、†, Shen Ji2, Qi Gu2,3,4, Zhen Gu1、*, and Yongqiang Wen1、**
Author Affiliations
  • 1School of Chemistry and Biological Engineering, University of Science and Technology Beijing, Haidian District, Beijing 100083, China
  • 2State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China
  • 3Beijing Institute for Stem Cell and Regenerative Medicine, Chaoyang District, Beijing 100101, China
  • 4University of Chinese Academy of Sciences, Huairou District, Beijing 100049, China
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    Wound dressing management is critical in healthcare, and frequent dressing changes for full-thickness skin wounds can hinder healing. Nanofiber dressings that resemble the extracellular matrix, have gained popularity in wound repair, however, it is challenging to explore how to frequently change it without affecting healing processing and avoiding secondary damage. Here, we developed a self-adhesive and detachable nanofiber dressing inspired by Andrias davidianus. Our asymmetric nanofiber dressing exhibits strong adhesion (26 kPa), to the wound at high temperature (approximately 25 °C) to the wound surface and can be easily detached (4 kPa) at low temperature (below 8 °C), enabling painless dressing changes that minimize secondary injuries. The dressing comprises an outer layer of polylactic acid which provides mechanical property, support, and pollution resistance, with an inner layer of nanofibrous membrane, composed of gelatin and Andrias davidianus skin secretions, which promotes cellular migration, enhances wound healing and possesses inherent antimicrobial properties. Furthermore, the all-natural nanofiber dressings can be prepared on a large scale and offer favorable biocompatibility to meet the basic requirements of wound dressings. These findings demonstrate the potential applicability of our multilayer nanofiber dressing for advancing wound healing practices.

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    Zhe Huang, Heng An, Haitao Guo, Shen Ji, Qi Gu, Zhen Gu, Yongqiang Wen. An Asymmetric Natural Nanofiber with Rapid Temperature Responsive Detachability Inspired by Andrias davidianus for Full-Thickness Skin Wound Healing[J]. Advanced Fiber Materials, 2024, 6(2): 00364

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    Paper Information

    Category: Research Articles

    Received: Sep. 8, 2023

    Accepted: Dec. 25, 2023

    Published Online: Jul. 5, 2024

    The Author Email: Gu Zhen (guzhen@ustb.edu.cn), Wen Yongqiang (wyq_wen@ustb.edu.cn)

    DOI:10.1007/s42765-023-00364-7

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