Influence ofelectro-oxidation of ascorbic acid was investigated under CW laser irradiation. It wasfound that oxide current dramatically increased and initial oxide potential evidentlydecreased with laser irradiation. The current increased by 5.71, 2.14, 3.02 times for GCE,graphite electrode and Au electrode, respectively. Initial oxide potential decreased by 50mV for both GCE and graphite electrode, by 250 mV for Au electrode. The thermal effectproceed by laser irradiation is mainly factor to cause the changes of oxide current andpotential, at the same time, electrode surface is likely activated to a certain extent dueto laser irradiation accelerating electrode reaction.