Based on the structural reconstruction ability of layered double hydroxides (LDHs), the nitrite intercalated LDHs were prepared. In this paper, nitrite intercalated LDHs was added into cement as a new type of chromium reducing admixture. Reduction efficiency, resistance to storage and stability under ball milling temperature conditions of nitrite intercalated LDHs were investigated. The mechanism of reduction and solidification of soluble Cr6+ in cement using nitrite intercalated LDHs was revealed. The results show that nitrite ions released from LDHs-NO2 interlayer mixing with water rapidly reduce soluble Cr6+ and effectively decrease soluble Cr6+ content in cement. The addition of 0.2%(mass fraction) LDHs-NO2 reduces the soluble Cr6+content in cement from 40.26 mg/kg to 9.36 mg/kg, and improves the compressive strength of cement by about 2 MPa. The reduced Cr3+ exchanges with Al3+ into LDHs laminate to achieve stable chemical solidification. The reduction efficiency of synthetic nitrite intercalated LDHs is better than FeSO4·7H2O. Furthermore, synthetic nitrite intercalated LDHs remains reductive stability when the cement is stored for a period and treated at ball mill temperature.