Dysprosium-doped lead thiogallate(Dy∶PbGa2S4, Dy∶PGS) crystal is a medium material for mid-infrared lasers with excellent performance and potential application value. To push forward its practical study, high quality large-sized Dy∶PGS single crystal is urgently required. In this study, an output of 230 g polycrystalline Dy∶PGS was successfully synthesized using a self-made two-zone furnace; a high quality Dy∶PGS single crystal with size of 27 mm×100 mm was grown by vertical gradient freezing method for the first time, and the Dy∶PGS crystal devices were achieved by cutting and polishing processes, laying a solid foundation for the further laser application research of this crystal.