In order to fabricate As2S8 stripe waveguide, experimental study on photo-induced refractive index and density changes in As2S8 film is reported. It is found that the refractive index, and density of As2S8 film are enhanced after UV illumination throught testing techniques of prism coupling, X-ray diffraction spectrum and far-infrared spectra of reflection. The visible light absorption spectra of the As2S8 film sample shows that photodarkening does not occur after UV light irradiation. Based on study of these phenomena, UV illumination technique is presented and applied to As2S8 stripe waveguide preparation. This stripe waveguide of As2S8 displays nice characteristic of conducting beam using through guide mode excitation by means of automatic alignment and end-face coupling technique.