With the restriction on natural sand mining, the use of manufactured sand has become an inevitable trend. Due to the significant differences in the formation processes of manufactured sand and natural sand, there are notable differences in their properties, which also affect the performance of manufactured sand concrete. In order to promote the application of manufactured sand and ensure that the workability and mechanical properties of manufactured sand concrete meet the required standards, this paper analyzes the influences of preparation method and particle characteristics of manufactured sand and proportion of concrete on the performance of concrete. The influences of manufactured sand parent rock lithology, stone powder content, particle morphology, gradation, and proportion of concrete on manufactured sand concrete are systematically summarized. Additionally, the limitations of existing research and the problems that need to be addressed are discussed to provide a reference for future research.