The performance of multi-cell systems has been seriously affected by inter-cell interference. In order to reduce the influence of inter-cell interference, the performance of multi-cell and multi-user multiple input multiple output visible light communication (MIMO-VLC) system is studied. The angle diversity receiver based on the hole is used as the receiving device, and the interference area is optimized by selecting the appropriate LED configuration, and two multi-cell implementation schemes are discussed. The first is dynamic cell division, and the second is photodetector selection(PDS) to eliminate inter-cell interference. The simulation results show that: when there are users in the interference zone in the cell, the dynamic cell division method has better bit error rate(BER) performance for the users in the cell, but the location of users in this cell will affect the performance of users in other cells, and its computational complexity is high. For PDS method to eliminate inter-cell interference, the BER performance of users in a cell is not affected by the location of users in other cells, and its computational complexity is low. When users are all in the non-interference zone, the BER performance of the two methods is the same.