Journal of Inorganic Materials, Volume. 36, Issue 9, 981(2020)
With good cytocompatibility, bioactivity, and slow degradation rate, hydroxyapatite (HAP) may remedy drawbacks of hyaluronan (HA) as soft tissue filler. Here, we prepared HA-HAP composite hydrogels by one-step reaction method, investigated various processing parameters on their physicochemical properties, and evaluated their biological performance. As-prepared HA-HAP composite hydrogels contained 1.5%-3.0% HA and 2.38%-15.8% HAP with good sterilization stability. Swelling-ratio and mechanical performance of the composite hydrogels could be adjusted by controlling HAP content and crosslinking reagent. The equilibrium swelling ratio achieved over 90% only after 1 h swell, and the swelling properties fitted well with 1st-order exponential decay equations. By 1500 U/mL HAase solutions, the composites degraded 95% after only 2 min and dispersed rapidly, showing good enzymatic degradability. HAP was demonstrated not only endowing the composite hydrogels with better plasticity for facial soft tissue filler and contour modification, but also providing good microenvironment for attachment and proliferation of fibroblasts. Therefore, the as-prepared HA-HAP composite could be used as a long-acting filler for remodeling extracellular matrix, and thus potentially applied in cosmetic medicine.
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Yutong ZHU, Peijie TAN, Hai LIN, Xiangdong ZHU, Xingdong ZHANG.
Category: RESEARCH ARTICLE
Received: Jan. 11, 2021
Accepted: --
Published Online: Dec. 9, 2021
The Author Email: LIN Hai (linhai028@scu.edu.cn)