Owing to the increasing demand of atmospheric sounding data with high precision and high temporal/spatial resolution, onboard infrared hyperspectral sounding systems, such as interferometer,are being developed extensively. Because of the inherent complicated optical structure of interferometer, the calibration precision is highly affected by the status of the instrument.The sensitivity characteristics of calibration precision were analyzed in this study, with regard to the status of the instrument, such as inner calibration blackbody (ICB) emissivity, low temperature external calibration blackbody (ECB) emissivity, temperature difference between the inner blackbody and environment, nonlinear coefficient and darkcurrent (DC) voltage.The results show that: The absolute value of calibration radiation deviation is linearly related to the emissivity of ICB/ECB, and has a positive correlation with the temperature difference between the ICB and environment, nonlinear coefficient, and DC voltage. To achieve the 0.1 K radiometric calibration accuracy, it is imperative to increase the emissivity of ICB/ECB to greater than 0.985. This controls the temperature difference between the ICB and environment, setting it at approximately 0.6 K and the nonlinear effect coefficient at less than 0.04. The influence of the radiometric calibration parameters on calibration radiation combined with the estimation of calibration parameters in the ground vacuum experiment enables initeratively obtaining the optimal estimation of the measured and unknown calibration parameters, thereby enhancing calibration accuracy. The findings of this study are highly significant in the design of the parameters of the infrared hyperspectral interferometer. They also aid in the identification and correction of the source of the radiometric calibration error.