Microfluidic plasma is a new process intensification strategy that combines the advantages of both microfluidic and plasma techniques. It can improve the uniformity and stability of the reaction process, control the reaction contact interface, and avoid rapid quenching of the species while increasing density of the active substances. This work summarizes representative radicals existed in microfluidic plasma and the relevant characterization techniques. Then, the microfluidic plasmas are classified into three categories based on the characteristic structure of the reactors. Afterwards, selective examples are given to demonstrate typical applications of the microfluidic plasma process intensification strategy, such as chemical synthesis, surface modification, nanomaterials preparation, contaminant detection, and biomedical purpose. Finally, the development trend of this technique is prospected.