Journal of Innovative Optical Health Sciences, Volume. 17, Issue 1, 2350020(2024)
Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer
Photodynamic therapy (PDT) has limited effects in treating metastatic breast cancer. Immune checkpoints can deplete the function of immune cells; however, the expression of immune checkpoints after PDT is unclear. This study investigates whether the limited efficacy of PDT is due to upregulated immune checkpoints and tries to combine the PDT and immune checkpoint inhibitor to observe the efficacy. A metastatic breast cancer model was treated by PDT mediated by hematoporphyrin derivatives (HpD-PDT). The anti-tumor effect of HpD-PDT was observed, as well as CD4
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Shan Long, Yibing Zhao, Yuanyuan Xu, Bo Wang, Haixia Qiu, Hongyou Zhao, Jing Zeng, Defu Chen, Hui Li, Jiakang Shao, Xiaosong Li, Ying Gu. Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer[J]. Journal of Innovative Optical Health Sciences, 2024, 17(1): 2350020
Category: Research Articles
Received: Feb. 2, 2023
Accepted: May. 14, 2023
Published Online: Feb. 28, 2024
The Author Email: Li Xiaosong (lixiaosong@hotmail.com), Gu Ying (guyinglaser301@163.com)