Journal of Innovative Optical Health Sciences, Volume. 11, Issue 1, 1830001(2018)
Applications of fluorescence lifetime imaging in clinical medicine
Fluorescence lifetime is not only associated with the molecular structure of fluorophores, but also strongly depends on the environment around them, which allows fluorescence lifetime imaging microscopy (FLIM) to be used as a tool for precise measurement of the cell or tissue microenvironment. This review introduces the basic principle of fluorescence lifetime imaging technology and its application in clinical medicine, including research and diagnosis of diseases in skin, brain, eyes, mouth, bone, blood vessels and cavity organs, and drug evaluation. As a noninvasive, nontoxic and nonionizing radiation technique, FLIM demonstrates excellent performance with high sensitivity and specificity, which allows to determine precise position of the lesion and, thus, has good potential for application in biomedical research and clinical diagnosis.
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Zhanwen Wang, Yanping Zheng, Deqiang Zhao, Ziwei Zhao, Lixin Liu, Artem Pliss, Feiqi Zhu, Jun Liu, Junle Qu, and Ping Luan. Applications of fluorescence lifetime imaging in clinical medicine[J]. Journal of Innovative Optical Health Sciences, 2018, 11(1): 1830001
Received: Jun. 8, 2017
Accepted: Jul. 21, 2017
Published Online: Sep. 17, 2018
The Author Email: Qu Junle (qujunle@szu.edu.cn)