To overcome the shortcomings of the existing safety control system of a large Unmanned Aerial Vehicle (UAV), we designed a portable Beidou ground station and an airborne BD safety controller by using Beidou short-message communication technology, which realized the passive safety control of Beidou short-message instructions and the self-judgment based active safety control of the safety control region.An independent MCU board was used as emergency backup device when the laptop failed, which could send control instructions by pressing a button and improve the reliability of instruction transmission. The mode of multiple portable Beidou ground stations working at the same time could effectively increase the frequentness of short-message sending.It is proved by practical application that its operation is smooth and reliable.The results show that the design of the UAV safety control system is reasonable and feasible, which can be applied to other UAV safety control systems.