Journal of Innovative Optical Health Sciences, Volume. 10, Issue 5, 1743002(2017)

Photon penetration depth in human brain for light stimulation and treatment: A realistic Monte Carlo simulation study

Ting Li1,*... Chang Xue2, Pengbo Wang2, Yan Li3 and Lanhui Wu2 |Show fewer author(s)
Author Affiliations
  • 1Institute of Biomedical Engineering, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, P. R. China 300192
  • 2State Key Lab Elect Thin Film & Integrated Device and Department of Biomedical Engineering, University of Electronic Science & Technology of China, Chengdu, P. R. China 610054
  • 3Design Center, Avic Beijing Keeven Aviation Instrument Co., Ltd, China Aviation Industry Corporation, Beijing, P. R. China 100098
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    Light has been clinically utilized as a stimulation in medical treatment, such as Low-level laser therapy and photodynamic therapy, which has been more and more widely accepted in public. The penetration depth of the treatment light is important for precision treatment and safety control. The issue of light penetration has been highlighted in biomedical optics field for decades. However, quantitative research is sparse and even there are conflicts of view on the capability of near-infrared light penetration into brain tissue. This study attempts to quantitatively revisit this issue by innovative high-realistic 3D Monte Carlo modeling of stimulated light penetration within high-precision Visible Chinese human head. The properties of light, such as its wavelength, illumination profile and size are concern in this study. We made straightforward and quantitative comparisons among the effects by the light properties (i.e., wavelengths: 660, 810 and 980 nm; beam types: Gaussian and flat beam; beam diameters: 0, 2, 4 and 6 cm) which are in the range of light treatment. The findings include about 3% of light dosage within brain tissue; the combination of Gaussian beam and 810 nm light make the maximum light penetration (> 5 cm), which allows light to cross through gray matter into white mater. This study offered us, the first time as we know, quantitative guide for light stimulation parameter optimization in medical treatment.

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    Ting Li, Chang Xue, Pengbo Wang, Yan Li, Lanhui Wu. Photon penetration depth in human brain for light stimulation and treatment: A realistic Monte Carlo simulation study[J]. Journal of Innovative Optical Health Sciences, 2017, 10(5): 1743002

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    Paper Information

    Received: Feb. 24, 2017

    Accepted: --

    Published Online: Jul. 14, 2020

    The Author Email: Li Ting (litinghaha9@126.com)

    DOI:10.1142/s1793545817430027

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