Two-dimensional (2D) transition-metal dichalcogenides have attracted much attention because of its small size and direct band gap properties, which can be used as an excellent luminescent medium in micro-nano optical structures. The 2D materials based micro-nano structure, such as optical microcavity and micro-nano sensor, are always obtained by the transferring method. However, contaminations and damage to the materials are hard to be avoided during material transfer, which will greatly affect the functionality of the structure. Direct growth of the 2D material on the micro/nano structure can solve this problem. WSe₂ is deposited directly on the surface of 6 μm-diameter SiO₂ sphere cavities by chemical vapor deposition (CVD) method, the compositional characterization of the materials on the microspheres proved that WSe₂ was grown on the microspheres, and it was proved that it is feasible to deposit two-dimensional materials on the curved surface by chemical vapor deposition. This 2D material based cavity is expected to be good candidates in high-performance optical sensors and light source devices. It also provides a basis for in-depth study of the exciton characteristics of two-dimensional materials in the high-strain condition induced by curved surface.