To study the influence of different materials on Fabry–Perot(F-P) interference acoustic sensor. An extrinsic F-P acoustic sensor based on the structure of fiber end-membrane was fabricated with several different metal diaphragm materials. Besides, the first-order natural frequency was obtained through simulating and analyzing the circular diaphragm using the method of finite element. Experimental results show that the sensor with gold diaphragm and zinc alloys diaphragm exhibit high sensitivity and good linear response property, and which can be detecting lower sound pressure.