In response to the diverse applications of avalanche photo-diode (APD), a design solution of bias circuit module with multi-mode control was proposed. Based on the working principles of APD, the correlation among gain coefficient, reverse bias voltage and operating temperature was analyzed. The bias circuit modules with multi-mode control were designed, the software design was realized on the single chip microcomputer, and the module was analyzed and verified by experiments. Experimental results show that the bias circuit module with multi-mode control and temperature compensation is available in the temperature range of -40~+60℃, the deviation of the output voltage is less than 0.5V, and the ripple is less than 100mV. The module can realize APD multi-mode operation and meet engineering applications.